Methadone hydrochloride tablets can cause life-threatening heartbeat problems that can lead to death. Most heartbeat problems have happened in people using large doses of methadone hydrochloride tablets for pain treatment.

The usual precautions appropriate to the use of parenteral opioids should Beryllium observed and the possibility of respiratory depression should always be kept rein mind.

Pharmacodynamic interactions may occur with concomitant use of methadone and potentially arrhythmogenic agents such as class I and III antiarrhythmics, some neuroleptics and tricyclic antidepressants, and calcium channel blockers.

A prescription for this medication isn’t refillable. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled.

Acute Pain – Maintenance patients on a stable dose of methadone World health organization experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should Beryllium administered analgesics, including opioids, hinein doses that would otherwise Beryllium indicated for non-methadone-treated patients with similar painful conditions.

Since methadone is lipophilic, it has been known to persist in the liver and other tissues. The slow release from the liver and other tissues may prolong the duration of methadone action despite low plasma concentrations.

Your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays rein your body for a longer time. This raises your risk of side effects.

“Doctor shopping” (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. However, it should Beryllium important to Beurteilung that preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control.

Opioid antagonists should not Beryllium administered hinein the absence of clinically significant respiratory or cardiovascular depression. Hinein an individual physically dependent on opioids, the administration of the usual dose of an opioid antagonist may precipitate an acute withdrawal syndrome.

Patients and their caregivers should be advised to discard unused methadone rein such a way that individuals other than the patient for whom it welches originally prescribed will not come in contact with the drug.

Patients should Beryllium instructed to keep methadone hinein a secure place out of the reach of children and other household members. Accidental or deliberate ingestion by a child may cause respiratory depression that can result hinein death.

Physicians should individualize treatment rein every case (see DOSAGE AND ADMINISTRATION), taking into account the high degree of interpatient variability rein response to and metabolism of methadone.

Although with single-dose administration the onset and duration of analgesic action, as well as the analgesic potency of methadone and morphine, are similar methadone's potency increases over time with repeated dosing. Furthermore, the conversion ratio between methadone and other opiates varies dramatically depending on baseline opiate (morphine equivalent) use as shown rein the table below.

Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its Methadontabletten 10 mg online peak analgesic effects, particularly in the early dosing period.